LightTrack OiS200 Mesoscope

The LightTrack OiS200 Mesoscope for optical imaging and targeted optogenetics is a highly customizable system for in vivo experimentation and behavioural research.

The mesoscope allows scientist perform in vivo imaging across the entire murine cortex as well as targeted optogenetics. The imaging of calcium indicators, intrinsic optical imaging, laser speckle imaging is easily performed with acquisition software that allows for with adjustable frame rate, exposure time, binning, ROI, illumination selection and stimulation parameters.

Users have found the system is ideal for integrating accessories used in behavioral studies as it synchronizes with various other types of behavioral equipment through auxiliary input/output ports.

The integrated and ergonomic system allows you to save lab space and comes at an economical price point making it an ideal research companion for neuroscience, vascular biology, saving 100 hundreds of hours required to build customized mesoscopic rig.

Publications

• Wang, C., Lin, C., Zhao, Y., Samantzis, M., Sedlak, P., Sah, P., & Balbi, M. (2023). 40-Hz optogenetic stimulation rescues functional synaptic plasticity after stroke Cell Reports, 42(12).
• Bakker, M.E., Djerourou, I., Belanger, S. et al. (2023). Alteration of functional connectivity despite preserved cerebral oxygenation during acute hypoxia Scientific Reports 13, 13269.
• Ashby, D. M., & McGirr, A. (2022). Selective effects of acute and chronic stress on slow and alpha-theta cortical functional connectivity and reversal with subanesthetic ketamine Neuropsychopharmacology, 1-11.
• Guilbert, J., & Desjardins, M. (2022). Movement correction method for laser specle contrast imaging of cerebral blood flow in cranial windows in rodents Journal of Biophotonics, 15(1), e202100218.
• Trigiani, Lianne J., Miled Bourourou, Maria Lacalle-Aurioles, Clotilde Lecrux, Amy Hynes, Shoshana Spring, Darren J. Fernandes et al. A functional cerebral endothelium is necessary to protect against cognitive decline Journal of Cerebral Blood Flow & Metabolism 42, no. 1 (2022): 74-89.
• Lacalle‐Aurioles, M., Trigiani, L. J., Bourourou, M., Lecrux, C., & Hamel, E. (2022). Alzheimer’s disease and cerebrovascular pathology alter inward rectifier potassium (KIR2.1) channels in endothelium of mouse cerebral arteries British Journal of Pharmacology, 179(10), 2259-2274.
• Trigiani, L. J., Lecrux, C., Royea, J., Lavoie, J. L., Lesage, F., Pilote, L., & Hamel, E. (2021). A Longitudinal Pilot Study on Cognition and Cerebral Hemodynamics in a Mouse Model of Preeclampsia Superimposed on Hypertension: Looking at Mothers and Their Offspring Frontiers in Physiology, 12, 611984.
• Zhang, S. Y., Jeffers, M. S., Lagace, D. C., Kirton, A., & Silasi, G. (2021). Developmental and interventional plasticity of motor maps after perinatal stroke Journal of Neuroscience, 41(28), 6157-6172.
• Laliberté, G., Othman, R., & Vaucher, E. (2020). Mesoscopic Mapping of Stimulus-Selective Response Plasticity in the Visual Pathways Modulated by the Cholinergic System Frontiers in Neural Circuits, 14, 38.
• Chouinard, V., Djerourou, I., Daigneault, V., Cortes, N., Laplante, L., Ptito, M., Lesage, F., Casanova, C., Vanni, M. (2022). Development of structured optogenetic stimulation in behaving animals for functional mapping of the mouse cortex Society for Neuroscience 2022, 499.14 / ZZ28.
• Djerourou, I., Morgan, E., Chouinard, V., Daigneault, V., Ptito, M., Vanni, M. (2022). Topographic integration of widefield patterned optogenetic stimulation in the mouse visual cortex Society for Neuroscience 2022, 546.09 / S3.
• Samantzis, M., Tainton-Heap, L., Balbi, M. (2022). Effects of 40Hz non-invasive brain stimulation on neural and behavioural changes following photothrombotic ischemic stroke Society for Neuroscience 2022, 203.14 / G16.
• Laliberté, G., Filion, A., Boire, D. (2022). Differential monosynaptic feedback circuitry of the HVAs to V1 in mouse Society for Neuroscience 2022, 469.20 / BB3.
• Sedighi, H., Fofana, A.-R., Choi, S., Guezzane, M., Li, Y., Vaucher, E. H. (2022). Mesoscopic mapping of the acetylcholine release and neuronal responses to variations of contrast in the mouse visual cortex Society for Neuroscience 2022, 714.10 / P16.
• Lu, X., Moeini, M., Li, B., Lu, Y., Damseh, R., Pouliot, P., … & Lesage, F. (2019). A Pilot Study Investigating Changes in Capillary Hemodynamics and Its Modulation by Exercise in the APP-PS1 Alzheimer Mouse Model Frontiers in Neuroscience, 13, 1261.
• Bélanger, S., de Souza, B. O. F., Casanova, C., & Lesage, F. (2016). Correlation of hemodynamic and fluorescence signals under resting state conditions in mice’s barrel field cortex Neuroscience Letters, 616, 177-181.
• Guevara, E., Sirpal, P., Abran, M., Pouliot, P., Lesage, F., Chen, J., … & Lodygensky, G. A. (2015, June). White matter injury in a newborn rat model analyzed with Resting-State Optical Imaging of Intrinsic Signals (rsOIS) In 2015 Photonics North (pp. 1-1). IEEE.