We are excited to announce the availability of our Ratiometric FRET Fiber Photometry System, and Multi-Wavelength Fiber Photometry System, designed to for neuroscience explorations with deep tech. Whether you are studying brain circuits in mice or rats, this photometry system delivers the high sensitivity and modularity necessary for today’s complex in vivo research.
The Ratiometric FRET Fiber Photometry System is equipped with Fluorescence Resonance Energy Transfer (FRET) technology, which ensures ultra-sensitive measurements of ratiometric biosensors. This system’s real-time data on calcium ion dynamics and neural activity help researchers better understand how specific neural populations respond to various stimuli, paving the way for new discoveries in fields such as behavioral neuroscience, neuropharmacology, and cognitive research.
With optional intensiometric biosensor support and correction channels for reflectance, the system provides the flexibility you need, making it an invaluable tool for your lab.
One of the standout features our new photometry systems, is that researchers can simultaneously use 4-fibers, which allows simultaneous monitoring of multiple subjects or brain regions. Each channel operates independently, eliminating the need for recalibration or realignment, saving time and improving accuracy.
Research needs often change, and our system is designed to adapt. With a wide selection of user-replaceable optical filters and laser sources, you can modify the setup to suit commercially available biosensors or your own custom biosensors. This level of modularity allows you to tailor the system to meet the specific requirements of your study, whether it’s focused on neural activity, neurotransmitter release, or metabolic changes.
With up to 8 analog inputs, the system can synchronize with other devices, adding another layer of customization to your experiments. These analog inputs can serve as triggers to start recordings, ensuring precise timing and integration with other laboratory systems.
The system’s powerful software platform offers comprehensive data analysis tools. It automatically displays FRET ratios and ΔF/F values, providing a clear measurement of changes in fluorescence relative to a baseline. The software also supports complex recording protocols, enabling you to run a series of acquisitions effortlessly.
Whether you’re monitoring neural activity over time or capturing responses to specific interventions, this system delivers the robust, reliable data you need for groundbreaking research.
In a recent Journal of Neuroscience Methods article, the Ratiometric FRET Fiber Photometry System was utilized for real-time neural activity monitoring in freely moving rodents. The system demonstrated exceptional sensitivity to calcium dynamics, providing high-resolution data on brain circuit function across multiple regions. With its FRET-based biosensors, the system enabled precise ratiometric measurements, allowing researchers to capture rapid neural responses with a ΔF/F ratio change sensitivity of up to 150%. This technology offers a groundbreaking approach to studying complex neural networks, paving the way for advancements in behavioral and cognitive neuroscience research.
Jones-Tabah J, Mohammad H, Hadj-Youssef S, Kim LEH, Martin RD, Benaliouad F, Tanny JC, Clarke PBS, Hébert TE. Dopamine D1 receptor signalling in dyskinetic Parkinsonian rats revealed by fiber photometry using FRET-based biosensors. Sci Rep. 2020 Sep 2;10(1):14426. doi: 10.1038/s41598-020-71121-8. PMID: 32879346; PMCID: PMC7468292.
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