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New Vascupaint™ Silicone Injection Compounds

Vascupaint Yellow Brain MicroCT

Vascupaint – The Modern Replacement for Flow-Tech’s Microfil®

When Flow-Tech Inc. discontinued its Microfil® vascular casting compound, many labs were left searching for a reliable alternative to support ongoing micro-CT and ex vivo vascular imaging studies.
Vascupaint™ from MediLumine is a modern, lead-free silicone injection compound designed to be a practical replacement for Microfil®, while supporting high-quality 3D visualization of the vasculature.

Why replace Microfil® with Vascupaint™?

Researchers who previously depended on Microfil® can transition to Vascupaint™ with minimal change to their workflow. Vascupaint™ was developed specifically for ex vivo vascular casting and is suitable for post-mortem injections in small animals and tissue specimens.

  • Continuity after Microfil® discontinuation
    Microfil® is no longer manufactured. Vascupaint™ provides an actively supported solution, helping ensure your vascular imaging protocols remain viable long term.
  • Lead-free formulation
    Vascupaint™ is lead-free, reducing handling concerns associated with traditional lead-based casting compounds while still providing strong attenuation for X-ray–based imaging.
  • Flow properties for microvasculature
    The formulation is designed to perfuse the vascular tree efficiently, helping the casting compound reach smaller vessels and capillaries when appropriate perfusion techniques are used.
  • Stable 3D casts for quantitative analysis
    Once cured, Vascupaint™ forms robust casts that are well suited for qualitative visualization and quantitative analysis of vascular networks.
  • Multiple colours and formats
    Vascupaint™ is available in Radiopaque Yellow for micro-CT, Green for NIR/SWIR-compatible workflows, and Clear for optical clearing and custom staining protocols.

CASE EXAMPLES

 

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Typical applications of Vascupaint™

Vascupaint™ can be used in many of the same applications where Microfil® was previously used, including:

  • Ex vivo micro-CT angiography in small animal models
  • Brain microvasculature and neurovascular mapping
  • Tumour angiogenesis and vascular remodelling studies
  • Cardiac, pulmonary, renal, and systemic vascular imaging
  • Developmental angiogenesis and microcirculation research
  • Method development for high-resolution 3D vascular imaging

Transitioning from Microfil® to Vascupaint™

If your lab is moving from Microfil® to Vascupaint™, most of the key steps in your protocol can remain similar:

  1. Preparation of the animal or fixed specimen.
  2. Cannulation of the target vessel (e.g., left ventricle, aorta, carotid, etc.).
  3. Flushing of the vasculature (e.g., with saline or heparinized solution, and optionally fixative).
  4. Controlled injection of the Vascupaint™ mixture.
  5. Curing, tissue processing, and imaging (e.g., micro-CT, optical clearing, microscopy).

Our team can help you fine-tune viscosity, injection rates, and curing times to match your existing setup and objectives. If you need support adapting your Microfil® protocol to Vascupaint™, please contact us—we are happy to review your workflow and make recommendations.

Product options and ordering

Vascupaint™ kits are supplied as a three-component system (silicone base, diluent, and catalyst). Standard options include:

  • Vascupaint™ Clear – suited for optical clearing, brightfield microscopy, and custom staining.
  • Vascupaint™ Yellow (radiopaque) – recommended for micro-CT and X-ray–based vascular imaging.
  • Vascupaint™ Green – designed for workflows that include NIR/SWIR or fluorescence imaging.

For detailed technical specifications, instructions for use, and current availability, please refer to the main Vascupaint™ product page or contact our team.

Replace Microfil® with Vascupaint™

Vascupaint™ offers a practical, supported alternative for high-quality ex vivo vascular casting.

View the Vascupaint™ product page |
Contact us for technical support

Related Pages:

Vascupaint™ Product Page

Related Products:

μAngiofil

Related Services:

Custom synthesis services

Product Information Sheet:

Download Vascupaint™ Certificate of Analysis 

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