Exia 160

Description

Binitio Biomedical’s radiocontrast agent for non-destructive and longitudinal MicroCT imaging. It is fully biodegradable and contains 160 mg of iodine per milliliter (mgI/mL) as an X-ray attenuating agent. Once injected intravenously, eXIA™160 shows blood residence time (clearance half-time of > 30 min) and then gets taken up by metabolically active organs such as the liver, spleen, myocardium and brown adipose tissue (BAT). eXIA™160 can prove useful for the non-invasive in vivo detection of liver and spleen abnormalities, myocardial infarction and cardiomyopathy, and to identify and quantify active brown adipose tissue (BAT). As such, it can be used to quantitatively determine the metabolic integrity of organs and tissues similarly to 2-Deoxy-2-[F]fluoro-D-glucose (FDG) positron emission tomography (PET), but without the need for a radioactive tracer.

Publications

Zuro D, Madabushi SS, Brooks J, Chen BT, Goud J, Salhotra A, Song JY, Parra LE, Pierini A, Sanchez JF, Stein A, Malki MA, Kortylewski M, Wong JYC, Alaei P, Froelich J, Storme G, Hui SK. First Multimodal, Three-Dimensional, Image-Guided Total Marrow Irradiation Model for Preclinical Bone Marrow Transplantation Studies. Int J Radiat Oncol Biol Phys. 2021 Nov 1;111(3):671-683. doi: 10.1016/j.ijrobp.2021.06.001. Epub 2021 Jun 11.
Xing R, De Wilde D, McCann G, Ridwan Y, Schrauwen JT, van der Steen AF, Gijsen FJ, Van der Heiden K. Contrast-enhanced micro-CT imaging in murine carotid arteries: a new protocol for computing wall shear stress. Biomed Eng Online. 2016 Dec 28;15(Suppl 2):156. doi: 10.1186/s12938-016-0270-2.
Ashton JR, Befera N, Clark D, Qi Y, Mao L, Rockman HA, Johnson GA, Badea CT. Anatomical and functional imaging of myocardial infarction in mice using micro-CT and eXIA 160 contrast agent. Contrast Media Mol Imaging. 2014 Mar-Apr;9(2):161-8. doi: 10.1002/cmmi.1557.
Xing R, Moerman AM, Ridwan RY, Gaalen KV, Meester EJ, van der Steen AFW, Evans PC, Gijsen FJH, Van der Heiden K. The effect of the heart rate lowering drug Ivabradine on hemodynamics in atherosclerotic mice. Sci Rep. 2018 Sep 18;8(1):14014. doi: 10.1038/s41598-018-32458-3.
Raes F, Sobilo J, Le Mée M, Rétif S, Natkunarajah S, Lerondel S, Le Pape A. High Resolution Ultrasound and Photoacoustic Imaging of Orthotopic Lung Cancer in Mice: New Perspectives for Onco-Pharmacology. PLoS One. 2016 Apr 12;11(4):e0153532. doi: 10.1371/journal.pone.0153532.
Clark DP, Badea CT. Micro-CT of rodents: state-of-the-art and future perspectives. Phys Med. 2014 Sep;30(6):619-34. doi: 10.1016/j.ejmp.2014.05.011. Epub 2014 Jun 26.
Chen PY, Qin L, Li G, Malagon-Lopez J, Wang Z, Bergaya S, Gujja S, Caulk AW, Murtada SI, Zhang X, Zhuang ZW, Rao DA, Wang G, Tobiasova Z, Jiang B, Montgomery RR, Sun L, Sun H, Fisher EA, Gulcher JR, Fernandez-Hernando C, Humphrey JD, Tellides G, Chittenden TW, Simons M. Smooth Muscle Cell Reprogramming in Aortic Aneurysms. Cell Stem Cell. 2020 Apr 2;26(4):542-557.e11. doi: 10.1016/j.stem.2020.02.013.
Lasnon C, Quak E, Briand M, Gu Z, Louis MH, Aide N. Contrast-enhanced small-animal PET/CT in cancer research: strong improvement of diagnostic accuracy without significant alteration of quantitative accuracy and NEMA NU 4-2008 image quality parameters. EJNMMI Res. 2013 Jan 17;3(1):5. doi: 10.1186/2191-219X-3-5.
Murtada SI, Kawamura Y, Caulk AW, Ahmadzadeh H, Mikush N, Zimmerman K, Kavanagh D, Weiss D, Latorre M, Zhuang ZW, Shadel GS, Braddock DT, Humphrey JD. Paradoxical aortic stiffening and subsequent cardiac dysfunction in Hutchinson-Gilford progeria syndrome. J R Soc Interface. 2020 May;17(166):20200066. doi: 10.1098/rsif.2020.0066. Epub 2020 May 27.
Deman P, Tan S, Belev G, Samadi N, Martinson M, Chapman D, Ford NL. Respiratory-gated KES imaging of a rat model of acute lung injury at the Canadian Light Source. J Synchrotron Radiat. 2017 May 1;24(Pt 3):679-685. doi: 10.1107/S160057751700193X. Epub 2017 Mar 21.
Clark DP, Badea CT. Advances in micro-CT imaging of small animals. Phys Med. 2021 Aug;88:175-192. doi: 10.1016/j.ejmp.2021.07.005. Epub 2021 Jul 17.
Tekabe Y, Kollaros M, Li Q, Zhang G, Li C, Schmidt AM, Johnson LL. Beneficial Effect of Glucose Control on Atherosclerosis Progression in Diabetic ApoE(-/-) Mice: Shown by Rage Directed Imaging. Int J Mol Imaging. 2014;2014:695391. doi: 10.1155/2014/695391. Epub 2014 Apr 14.
Ashton JR, West JL, Badea CT. In vivo small animal micro-CT using nanoparticle contrast agents. Front Pharmacol. 2015 Nov 4;6:256. doi: 10.3389/fphar.2015.00256.
Schürmann C, Gremse F, Jo H, Kiessling F, Brandes RP. Micro-CT Technique Is Well Suited for Documentation of Remodeling Processes in Murine Carotid Arteries. PLoS One. 2015 Jun 18;10(6):e0130374. doi: 10.1371/journal.pone.0130374.
Tekabe Y, Kollaros M, Zerihoun A, Zhang G, Backer MV, Backer JM, Johnson LL. Imaging VEGF receptor expression to identify accelerated atherosclerosis. EJNMMI Res. 2014 Dec;4(1):41. doi: 10.1186/s13550-014-0041-7. Epub 2014 Aug 1.
Befera NT, Badea CT, Johnson GA. Comparison of 4D-microSPECT and microCT for murine cardiac function. Mol Imaging Biol. 2014 Apr;16(2):235-45. doi: 10.1007/s11307-013-0686-z.
van der Pluijm I, van Vliet N, von der Thusen JH, Robertus JL, Ridwan Y, van Heijningen PM, van Thiel BS, Vermeij M, Hoeks SE, Buijs-Offerman RMGB, Verhagen HJM, Kanaar R, Bertoli-Avella AM, Essers J. Defective Connective Tissue Remodeling in Smad3 Mice Leads to Accelerated Aneurysmal Growth Through Disturbed Downstream TGF-β Signaling. EBioMedicine. 2016 Oct;12:280-294. doi: 10.1016/j.ebiom.2016.09.006. Epub 2016 Sep 10.
Hellberg S, Silvola JM, Kiugel M, Liljenbäck H, Metsälä O, Viljanen T, Metso J, Jauhiainen M, Saukko P, Nuutila P, Ylä-Herttuala S, Knuuti J, Roivainen A, Saraste A. Type 2 diabetes enhances arterial uptake of choline in atherosclerotic mice: an imaging study with positron emission tomography tracer ¹⁸F-fluoromethylcholine. Cardiovasc Diabetol. 2016 Feb 6;15:26. doi: 10.1186/s12933-016-0340-6.
Stark K, Philippi V, Stockhausen S, Busse J, Antonelli A, Miller M, Schubert I, Hoseinpour P, Chandraratne S, von Brühl ML, Gaertner F, Lorenz M, Agresti A, Coletti R, Antoine DJ, Heermann R, Jung K, Reese S, Laitinen I, Schwaiger M, Walch A, Sperandio M, Nawroth PP, Reinhardt C, Jäckel S, Bianchi ME, Massberg S. Disulfide HMGB1 derived from platelets coordinates venous thrombosis in mice. Blood. 2016 Nov 17;128(20):2435-2449. doi: 10.1182/blood-2016-04-710632. Epub 2016 Aug 29.
Rose M, Kloten V, Noetzel E, Gola L, Ehling J, Heide T, Meurer SK, Gaiko-Shcherbak A, Sechi AS, Huth S, Weiskirchen R, Klaas O, Antonopoulos W, Lin Q, Wagner W, Veeck J, Gremse F, Steitz J, Knüchel R, Dahl E. ITIH5 mediates epigenetic reprogramming of breast cancer cells. Mol Cancer. 2017 Feb 23;16(1):44. doi: 10.1186/s12943-017-0610-2.
Lusic H, Grinstaff MW. X-ray-computed tomography contrast agents. Chem Rev. 2013 Mar 13;113(3):1641-66. doi: 10.1021/cr200358s. Epub 2012 Dec 5.
von Brühl ML, Stark K, Steinhart A, Chandraratne S, Konrad I, Lorenz M, Khandoga A, Tirniceriu A, Coletti R, Köllnberger M, Byrne RA, Laitinen I, Walch A, Brill A, Pfeiler S, Manukyan D, Braun S, Lange P, Riegger J, Ware J, Eckart A, Haidari S, Rudelius M, Schulz C, Echtler K, Brinkmann V, Schwaiger M, Preissner KT, Wagner DD, Mackman N, Engelmann B, Massberg S. Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo. J Exp Med. 2012 Apr 9;209(4):819-35. doi: 10.1084/jem.20112322. Epub 2012 Mar 26.
Heroux J, Gharib AM, Danthi NS, Cecchini S, Ohayon J, Pettigrew RI. High-affinity alphavbeta3 integrin targeted optical probe as a new imaging biomarker for early atherosclerosis: initial studies in Watanabe rabbits. Mol Imaging Biol. 2010 Jan-Feb;12(1):2-8. doi: 10.1007/s11307-009-0242-z.

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Receive a Free Wallchart to Help with Mouse Tail Vein Injections

Exia 160

Description

Publications

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