Binaree tissue clearing reagents render intact tissue optically transparent while preserving endogenous fluorescence and antibody labeling, so whole brains, organs, and tumors can be imaged in three dimensions without physical sectioning. The chemistry is water-based, which means samples avoid the harsh solvent and dehydration steps that quench signal in many clearing protocols, and the workflow is a simple immersion series that needs no perfusion or electrophoretic hardware. Cleared samples pair naturally with light-sheet, confocal, and two-photon imaging across neuroscience, oncology, developmental biology, and organoid research.