Angiofil

Description

Mixture of esters (mainly ethyl esters) of polyiodinated fatty acids. For mouse imaging, product is mixed with liquid paraffin at a 1 to 5 ratio, organs are harvested in paraformaldehyde or the specimen is imaged during the perfusion. No tissue clearing is required.

Oily contrast agent
High radio opacity
No mixture with remaining blood
No oedematisation of the surrounding tissue
No extravasation on corporal cavities

Zangpo D, Nakane H, Iino M. Vascular anatomy and their variations in Situs inversus totalis using postmortem computed tomographic angiography. Anat Cell Biol. 2023 Mar 31;56(1):155-159. doi: 10.5115/acb.22.213. Epub 2022 Dec 20.
Egger C, Dédouit F, Schrag B, Hanquinet S, Fracasso T. A forensic case of hydranencephaly in a preterm neonate fully documented by postmortem imaging techniques. Forensic Sci Res. 2023 Jan 13;8(1):79-83. doi: 10.1093/fsr/owad002.
Stumm CJ, Wittig H, Kalberer NM, Scheurer E. Histomorphological assessment of isolated abdominal organs after targeted perfusion with the contrast agent Angiofil® in postmortem computed tomography angiography. Forensic Sci Int. 2020 Oct;315:110427. doi: 10.1016/j.forsciint.2020.110427. Epub 2020 Jul 24.
Blaettler C, Kaessmeyer S, Grabherr S, Koch C, Schweizer D, Van der Vekens E. Post-mortem Computed Tomographic Angiography in Equine Distal Forelimbs: A Feasibility Study. Front Vet Sci. 2022 May 11;9:868390. doi: 10.3389/fvets.2022.868390.
Rotzinger DC, Magnin V, van der Wal AC, Grabherr S, Qanadli SD, Michaud K. Coronary CT angiography for the assessment of atherosclerotic plaque inflammation: postmortem proof of concept with histological validation. Eur Radiol. 2024 Mar;34(3):1755-1763. doi: 10.1007/s00330-023-10169-2. Epub 2023 Sep 2.
Colleter R, Dedouit F, Duchesne S, Gérard P, Dercle L, Poilpré P, Gendrot V, Rousseau H, Crubézy É, Telmon N, Mokrane FZ. Study of a seventeenth-century French artificial mummy: autopsical, native, and contrast-injected CT investigations. Int J Legal Med. 2018 Sep;132(5):1405-1413. doi: 10.1007/s00414-018-1830-8. Epub 2018 Mar 28.
Steuwe A, Boeven J, Cordes L, Draisci S, Boos J, Grabherr S, Bruguier C, Dalyanoglu H, Antoch G, Aissa J. Impact of increasing levels of adaptive statistical iterative reconstruction on image quality in oil-based postmortem CT angiography in coronary arteries. Int J Legal Med. 2021 Sep;135(5):1869-1878. doi: 10.1007/s00414-021-02530-1. Epub 2021 Feb 24.
Sawall S, Klein L, Wehrse E, Rotkopf LT, Amato C, Maier J, Schlemmer HP, Ziener CH, Heinze S, Kachelrieß M. Threshold-dependent iodine imaging and spectral separation in a whole-body photon-counting CT system. Eur Radiol. 2021 Sep;31(9):6631-6639. doi: 10.1007/s00330-021-07786-0. Epub 2021 Mar 13.
Maloca PM, Williams EA, Mushtaq F, Rueppel A, Müller PL, Lange C, de Carvalho ER, Inglin N, Reich M, Egan C, Hasler PW, Tufail A, Scholl HPN, Cattin PC. Feasibility and tolerability of ophthalmic virtual reality as a medical communication tool in children and young people. Acta Ophthalmol. 2022 Mar;100(2):e588-e597. doi: 10.1111/aos.14900. Epub 2021 May 14.
Utukuri PS, Lefkowitch JH, Erde SM, Smithgall M, Makkar J, Weintraub JL, Bernd P. Student-Authored Autopsy Reports of Anatomical Donors: Their First Patients. Med Sci Educ. 2020 Aug 17;30(4):1405-1411. doi: 10.1007/s40670-020-01054-4.
Webb B, Widek T, Scheicher S, Schwark T, Stollberger R. Post-mortem MR angiography: quantitative investigation and intravascular retention of perfusates in ex situ porcine hearts. Int J Legal Med. 2018 Mar;132(2):579-587. doi: 10.1007/s00414-017-1763-7. Epub 2018 Jan 18.
Leyssens L, Pestiaux C, Kerckhofs G. A Review of Ex Vivo X-ray Microfocus Computed Tomography-Based Characterization of the Cardiovascular System. Int J Mol Sci. 2021 Mar 23;22(6):3263. doi: 10.3390/ijms22063263.
Rechtsmedizin (Berl). 2022;32(4):320-354. German. [101st International Annual Meeting of the German Society of Forensic Medicine]. doi: 10.1007/s00194-022-00580-2. Epub 2022 Jul 27.
Grabherr S, Heinemann A, Vogel H, Rutty G, Morgan B, Woźniak K, Dedouit F, Fischer F, Lochner S, Wittig H, Guglielmi G, Eplinius F, Michaud K, Palmiere C, Chevallier C, Mangin P, Grimm JM. Postmortem CT Angiography Compared with Autopsy: A Forensic Multicenter Study. Radiology. 2018 Jul;288(1):270-276. doi: 10.1148/radiol.2018170559. Epub 2018 May 1.

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Angiofil

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