Fenestra HDVC

Description

Fenestra HDVC™ is a biomimetic nanoemulsion contrast agent designed to deliver exceptional soft tissue visualization in microCT imaging for preclinical research. Engineered to closely mimic naturally circulating chylomicron remnants, it is the only hepatocyte-selective contrast agent available for preclinical use, allowing researchers to achieve high-resolution imaging of organs, vascular systems, and soft tissues across PET-CT and SPECT-CT modalities. Its modified vitamin E-based formulation makes it safe and non-toxic, rendering it well-suited for longitudinal in vivo studies. Fenestra HDVC™ can be administered either intravenously (IV) or intraperitoneally (IP) — with IV injection providing immediate vascular contrast, while IP injection offers a convenient alternative with blood pool visualization achievable at 24 hours post-injection and liver and spleen contrast at 48 hours. In oncology research, it enhances the visualization of liver and pancreatic tumors — including small masses — while also supporting detailed organ imaging for drug biodistribution studies and the evaluation of therapeutic interventions. Its versatility makes it a valuable tool across a broad range of preclinical applications, from cancer research and drug development to therapy assessments.

MicroCT contrast enhancement following surgical implantation of B16F10 tumor cells in eight week old C57BL/6 male mice. ref. Tan, M.J., Fernandes, N., Williams, K.C. et al. In vivo micro-computed tomography imaging in liver tumor study of mice using Fenestra VC and Fenestra HDVC. Sci Rep 12, 22399 (2022). https://doi.org/10.1038/s41598-022-26886-5

Interested in testing out Fenestra HDVC for liver tumors? Ask us about our CRO services for scanning excised livers with microCT.

USD $405

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