Introducing the DEXA InAlyzer2: A Comprehensive Solution for Bone Density and Body Composition Analysis

The InAlyzer 2 is a specialized DEXA (Dual-Energy X-ray Absorptiometry) system designed for precise and reliable measurements of bone mineral density (BMD) and body composition in small animal research. This system supports a wide range of metabolic and musculoskeletal studies, providing researchers with high-resolution data for various experimental models.

DEXA for Bone Mineral Density Research

DEXA scanning is widely recognized as the standard method for assessing BMD in small animal models used in metabolic bone disease research. Laboratory rats and mice are frequently employed in osteoporosis studies due to their physiopathologic similarities to humans.

Applications in Osteoporosis Research

Researchers utilize rat and mouse models for various osteoporosis-related interventions, including:

• Hormonal manipulations (ovariectomy, orchidectomy, hypophysectomy, parathyroidectomy)
• Immobilization studies
• Dietary modifications

The InAlyzer 2 enables detailed skeletal analysis by providing real-time imaging during data acquisition. Researchers can monitor the study animal live while capturing high- and low-energy images, ensuring accurate and consistent measurements.

Comprehensive Bone Measurement Capabilities

The InAlyzer 2 offers advanced analysis through:

• Multiple regions of interest (ROI) selection for focused measurements on areas such as the hindlimbs or spine
• The ability to scan multiple excised samples simultaneously, analyzing each specimen individually
• A fan-beam system with a super-flattening technique, allowing multiple small animals to be scanned at once or analyzed separately via ROI segmentation

DEXA for Body Composition Analysis

In addition to bone density measurements, DEXA technology is widely applied in assessing whole-body composition in small animal models. Originally developed for noninvasive bone density assessment, DEXA is now an essential tool for body composition studies, offering precise quantification of bone mineral content (BMC), fat, and lean mass.

Accurate and Reproducible Body Composition Data

The InAlyzer 2 provides:

• High accuracy and reproducibility of data across both lean and obese animal models
• Strong correlation between DEXA body composition results and traditional chemical analysis methods, with the advantage of being noninvasive and significantly faster

Advanced Body Composition Imaging

Using dual-energy X-ray technology, DEXA distinguishes different tissue types based on their unique attenuation signatures. This enables precise analysis of:

• BMC (Bone Mineral Content)
• Fat distribution
• Lean tissue mass

The system’s software enhances body composition studies with:

• Overlay imaging to visualize bone, lean tissue, and fat in a single comprehensive view
• User-defined ROI selection for targeted analysis of specific body regions
• Color-coded composition images for rapid identification of high-fat regions

Versatile Imaging Modes

The InAlyzer 2 offers multiple analytical imaging options to support various research needs:

• High-resolution X-ray images
• Bone structure imaging
• Tissue-specific imaging
• Comprehensive body composition mapping

Conclusion

The InAlyzer 2 is a powerful and versatile tool for small animal research, offering precise bone density and body composition analysis. With its advanced imaging capabilities, real-time monitoring, and customizable analysis options, the system enhances the accuracy and efficiency of preclinical studies in metabolic, musculoskeletal, and obesity research. By integrating high-resolution DEXA scanning with flexible software features, the InAlyzer 2 provides researchers with a reliable and comprehensive solution for their investigative needs.