ExiTron™ BAT is a CT contrast agent developed for in vivo imaging of brown adipose tissue in small animal models. It is intended for researchers studying energy metabolism, thermogenesis, and metabolic disorders where accurate identification of brown fat depots is required. The formulation contains an iodine based amphiphilic component that preferentially accumulates in brown adipose tissue, enabling reliable differentiation from surrounding tissues in preclinical CT studies. Ordering through an authorized distributor provides access to validated logistics, technical assistance, and application level support.
Left: Sagittal CT image of a mouse at 3.5 hours post injection of ExiTron BAT showing contrast enhancement in the intrascapular BAT
Right: Timecourse of ExiTron BAT uptake in BAT of young mice with and without BAT activation via short-term cold exposure. Specifi c accumulation of the contrast agent in activated BAT enables visualization of this tissue with ease.
Brown adipose tissue plays a central role in metabolic regulation, yet its visualization using conventional CT approaches is challenging due to limited tissue contrast. ExiTron™ BAT addresses this limitation by selectively accumulating in brown fat depots, producing sufficient X ray attenuation to allow clear identification and analysis. The agent supports extended imaging windows, making it suitable for studies that require flexible acquisition timing and repeated measurements.
Following administration, ExiTron™ BAT shows pronounced accumulation in brown adipose tissue such as interscapular and cervical depots. The resulting contrast enhancement allows precise delineation of BAT morphology and volume. Uptake profiles support longitudinal assessment, enabling monitoring of structural changes over time as well as evaluation of BAT activation under different physiological or experimental conditions.
ExiTron™ BAT is applied in preclinical CT studies focused on visualization and quantification of brown adipose tissue. Typical applications include assessment of BAT distribution, volumetric analysis, and longitudinal monitoring of morphological changes. The agent is also suitable for studies investigating BAT activation, for example in response to cold exposure or metabolic interventions.
ExiTron™ BAT consists of nanoparticles designed to support tissue specific uptake and imaging stability. The mean hydrodynamic diameter is approximately 320 nanometers. Undiluted X ray attenuation reaches approximately 8000 Hounsfield units, providing adequate contrast for BAT visualization in micro CT systems.
Preclinical imaging studies demonstrate clear enhancement of brown adipose tissue following ExiTron™ BAT administration. Time course analyses show selective uptake in BAT, with increased signal observed in activated tissue compared to non activated controls. These characteristics support reproducible identification of brown fat depots across experimental conditions.
The application of ExiTron™ BAT has been presented in preclinical imaging research, including reports on CT visualization of activated brown adipose tissue in small animal models at international molecular imaging conferences.
ExiTron™ BAT is available in packaging formats suitable for exploratory studies or extended experimental series, including options containing one set of five injections or five sets of five injections. Ordering through an authorized distributor enables local availability, institutional purchasing support, and custom quotations.
Supporting documentation includes a detailed product data sheet describing formulation characteristics, recommended use, and imaging considerations for brown adipose tissue studies.
Authorized distributor of Viscover products by Nanopet Pharma GmbH. This page contains original distributor specific content intended to support preclinical CT imaging of brown adipose tissue.
Price range: USD $719 through USD $3,329
