GadoSpin™ V is an extracellular gadolinium-based MRI agent adapted from clinically established gadoxetate disodium formulations for preclinical liver imaging. The agent accumulates in hepatocytes through active transport, providing positive contrast enhancement in healthy liver tissue and enabling precise detection of focal liver lesions.
GadoSpin™ V is suitable for evaluating liver morphology, detecting and characterizing liver tumors and metastases, and differentiating between malignant and benign lesions. Its hepatocyte-specific uptake ensures clear visualization of even small hepatic lesions in preclinical T1-weighted MRI studies.
Relaxivity at 37 °C and 1.5 T is r1 = 7 L mmol-1 s-1 and r2 = 9 L mmol-1 s-1 in plasma, with r1 = 7 L mmol-1 s-1 in blood. The molecular weight is 726 g mol-1. These properties support predictable liver enhancement and reproducible imaging outcomes.
Structural formula of Gd-EOB-DTPA Disodium
The agent provides robust positive contrast in hepatocytes, enables early and accurate detection of liver lesions, and serves as a well-validated reference for liver imaging in small animal models.
T1-weighted FSE images of mouse abdomen demonstrate hyperintensity of healthy liver tissue after GadoSpin™ V administration, clearly highlighting hepatocyte-specific accumulation and supporting quantitative and longitudinal studies.
GadoSpin™ V is available in single and multiple injection packs. Authorized distributor channels provide local support, technical guidance, and timely delivery for preclinical research applications.
Authorized distributor of Viscover products by Nanopet Pharma GmbH. This content is uniquely developed for distributor-specific preclinical imaging applications using GadoSpin™ V.
Price range: USD $325 through USD $1,502
