The Bright Instruments 9150 Cryostat is an advanced system meticulously engineered for the precise cryosectioning of exceptionally large specimens, including entire organs, where conventional cryostats are insufficient. Drawing upon over five decades of expertise in cryostat development, the 9150 is designed to facilitate whole organ sectioning while scrupulously preserving critical tissue architecture and molecular integrity. This makes it an indispensable tool for cutting-edge research requiring high-fidelity sample preparation.
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The 9150 Cryostat is distinguished by its substantial capacity, accommodating specimens up to 110 mm (H) x 150 mm (W) x 150 mm (L). Researchers gain precise control over section thickness, which is adjustable from 5 µm to 200 µm in 1 µm increments. This extensive range supports a broad spectrum of research requirements, from routine histological analysis to complex, detailed whole organ studies.
Operation is streamlined through a centralized touchscreen control panel, offering intuitive management of temperature, section thickness, and batch quantities. This interface allows for seamless switching between single and continuous cutting modes, enabling precise workflow customization to align with diverse and demanding sectioning protocols.
Acknowledging the unique requirements of specialized research, the Bright Instruments 9150 Cryostat is a made-to-order system. It provides optional design modifications to ensure precise alignment with specific customer specifications. This customizability positions it as an ideal solution for core facilities and research groups focused on detailed protein localization or spatial gene expression studies across entire organ structures.
The Bright Instruments 9150 Cryostat is developed for a wide array of applications across medical research, histology, and the life sciences, extending into specialized industrial sectors. It facilitates the precise preparation of large biological samples, which is essential for advanced investigation and the preservation of critical cellular and molecular information.
Specific biological applications include detailed studies in neuroscience, such as the cryosectioning of whole monkey and human brains. It also serves cardiology and renal research for analyzing whole human hearts and kidneys, and supports investigations in immunology and organ biology through the sectioning of whole human spleens, as well as partial human liver and lung tissues.
Crucially, this system supports advanced molecular and cellular analysis techniques including immunohistochemistry, in situ hybridization, and spatial transcriptomics. Its unparalleled capability to preserve tissue architecture, cellular integrity, and molecular composition is paramount for high-resolution molecular mapping, protein localization, and comprehensive gene expression studies within intact organs.
Beyond biological specimens, the 9150 Cryostat is also suitable for materials and industrial research. It enables the analysis of large tissue-like specimens or composite materials, extending its utility to diverse scientific disciplines, including automotive and forestry studies.
Patent: GB1803310.0
