Description
The OTF7000 Cryostat is designed to deliver reproducible frozen tissue sections with precise and stable temperature control. Engineered for high throughput laboratories, it supports a wide range of clinical, research, and industrial applications.
Two models are available:
- OTF7000 semi-automated cryostat
- OTF7000/A fully automated cryostat with motorised sectioning
Both models offer consistent section quality and advanced features to meet demanding cryosectioning requirements.
Key Applications
The OTF7000 Cryostat is suitable for applications where precision and reproducibility are critical:
Clinical Histology and Pathology
- Intraoperative frozen section analysis
- Tumor profiling and metastasis detection
- Assessment of treatment efficacy
Immunohistochemistry
- Protein localization
- Analysis of cellular markers, antigens, and disease markers
Developmental Biology
- Organogenesis and cellular differentiation studies
- Stem cell and tissue engineering research
- Molecular tissue composition analysis at different developmental stages
Pharmacology and Toxicology
- Evaluation of therapeutic outcomes
- Pharmacokinetic and biodistribution studies
Immunology and Infectious Disease
- Distribution of pathogens and immune cells
- Inflammation response analysis
- Autoimmune disease research
Spatial Transcriptomics
- Mapping gene expression within tissue architecture at high spatial resolution
- Proper cryosectioning ensures optimal data acquisition
Neurology, Cardiology, Oncology, and Other Non-Infectious Diseases
- Study of disease progression and pathological features
- Cellular and molecular changes analysis
- Gene expression and disease mechanism studies
High Precision Temperature Control
The OTF7000 Cryostat maintains stable temperatures and reproducible sectioning performance with:
- Cryochamber temperature range 0 to –35°C
- Variable speed compressor for consistent cooling
- Sample cooling system with adjustable range from –10°C to –50°C via Peltier cooling
- Cryobar sample preparation station reaching –60°C for rapid tissue freezing
- Intelligent temperature control system for precise regulation
Stable and Accurate Sectioning
Section quality is maintained through advanced mechanical design:
- Precision cross roller guide rails for smooth and accurate sectioning
- Screw rods meeting 0.5 µm sample injection requirements
- Five-phase, high resolution stepping motor for low vibration and precise positioning
- Horizontal sampling slide made from corrosion-resistant, aviation-grade aluminium
Motorised sectioning in the OTF7000/A model enhances reproducibility and reduces operator variability.
Integrated Safety Features
The OTF7000 Cryostat includes multiple safety and ergonomic features:
- Low-temperature UVC disinfection system kills bacteria and viruses at intensity above 340 µW/cm²
- Ergonomic cabinet with circular arc design and optional height-adjustable footrest
- Optional section waste removal system for minimal manual cleaning
- Waste management system with real-time display of liquid volume
- Alarm notification when waste container reaches capacity
Efficient Operation and Energy Saving
The OTF7000 Cryostat is designed for operational efficiency and minimal energy use:
- 7-inch touch-sensitive screen for intuitive control
- Joystick control for trimming, coarse sampling, and section switching
- ±8° visual pointer for precise specimen clamp positioning, reducing trimming and sample waste
- Auto-sectioning mode for consistent results
- Multiple defrosting options and automatic sleep/wake function
- Single-lever specimen loading and marking for easy sample identification
Additional Features
- Wide range of compatible accessories to optimize laboratory workflow
- Motorised sectioning option in OTF7000/A for fully automated cryosectioning
- UVC disinfection for user safety with all biological specimens
- Individually controlled specimen holder and chamber temperatures
