Description
The Bright Instruments 10400 Cryostat is a highly specialised, patent-protected system designed for whole human brain sectioning and other large specimens. Developed from our 9400 Cryostat, it has been engineered to handle larger tissue volumes while maintaining structural integrity and molecular fidelity.
Patent: GB18031310
Whole brain sectioning is critical for neuroscience research, enabling detailed study of brain-wide structures, neural circuits, and pathological features. Proper cryosectioning preserves the intricate architecture of the brain, supporting accurate mapping of gene expression, cellular distribution, and protein localization.
Applications
The 10400 Cryostat is suited to advanced neuroscience research and clinical studies, including:
- Developmental Neuroscience: Mapping structural and cellular changes during brain development
- Neurodegenerative Disease Research: Studying protein aggregation, neural degeneration, and disease progression
- Functional Brain Mapping: Analyzing neural circuits, connectivity, and gene expression patterns
- Proteomics and Molecular Analysis: Preserving molecular and cellular integrity for protein, neurotransmitter, and gene expression studies
- Clinical Neuropathology: Coronal sectioning for visualization of critical brain structures in large-scale anatomical studies
Key Features
Adjustable Deep-Freezing Temperature
- Maintains cellular and molecular integrity during sectioning
- Supports studies requiring precise protein, neurotransmitter, or gene expression analysis
Large Chamber Design
- Deep chamber accommodates whole human brains and other large specimens
- Enables coronal sectioning for comprehensive structural analysis
- Customisable specifications available for research-specific applications
Touchscreen Control Panel
- Centralised control for all unit settings
- Adjustable section thickness, temperature, and batch quantities
- Switch between single and continuous cutting modes for workflow flexibility
Customisation and Flexibility
The 10400 Cryostat is manufactured to order, allowing laboratories to specify additional design features to meet specific research needs. Contact Bright Instruments to discuss custom configurations for large-scale tissue sectioning projects.
